COLONIZATION OF MUSCOSAL SURFACES

A presentation of the opposing evolutionary forces that ultimately determine the health of host organisms and survival of pathogenic microorganisms.
· Provides an in-depth examination of the complex ecosystems of the mammalian mucosa and the successful adaptations of microorganisms that enable them to effectively colonize these surfaces.
· Covers colonization of the respiratory tract, the gastrointestinal tract, and the genitourinary tract and considers the various organisms present at these surfaces.
· Contemplates aspects of bacterial colonization revealed by the most recent research including penetration of the mucous layer, innate immune effectors and their subversion, signaling of host cells by adherence factors, modulation of adherence, phase variation of colonization factors, and regulation of colonization effectors.